PSMA-targeted radiopharmaceuticals have brought theranostics into the clinical spotlight—but what comes next? In this episode, host Dr. Mike Nickels is joined by Dr. Anna Wu (City of Hope) for a wide-ranging discussion on the future of theranostics beyond PSMA. Together, they explore what makes a strong theranostic target, how evolving tumor biology and heterogeneity are shaping next-generation agents, and why pan-cancer and tumor-microenvironment targets are gaining momentum. The conversation also dives into combination strategies, alpha-emitters, clinical translation challenges, and what the next decade may hold for the field. A must-listen for scientists, clinicians, and anyone interested in where theranostics is headed next.