50,000 researchers. 400,000 downloads. Used in COVID vaccine validation, Great Barrier Reef science, cancer treatment development, and CRISPR research. And it nearly collapsed because there was no money to maintain it. Mixomics co-founders Kim-Anh Lê Cao and Mike Rennie sit down with Clint and Andrew to talk about building a global scientific standard on no budget, the big bet of going from academic project to real company, and why their biggest bad call was letting other people's doubt become their own.