
Sign up to save your podcasts
Or


So you thought you could keep a secret? Well, now every secret encoded in your DNA is about to be sold to the highest bidder as the genetic testing company 23andMe goes into Chapter 11 bankruptcy protection.
Now the millions of people who paid $99 to check their DNA, hoping to learn about their ancestry, lost siblings, or hereditary disease, are wondering who’s now gonna know everything about them. Co-founder and CEO Anne Wojcicki, who took the company from nothing to a $6 billion valuation and back down to $14 million on Wednesday, said she’ll stay on as interim CEO and will mount her own third bid to buy the company, but this time the board of directors that nixed her first two lowball offers has itself resigned.
23andMe’s problems seem endemic to its business model: Faced with the realization that there’s no such thing as a recurring customer in this business (consumers have their DNA tested once, and unless they live near Chernobyl, their genetic makeup is unlikely to change), Wojcicki hoped to boost the firm’s fortunes by taking the DNA of its customers and using it to create wonder drugs. That failed—drug-making is expensive! That’s left the bank of 15 million-plus DNA samples in line to be sold.
Should 23andMe customers be worried? A company spokesperson told The Washington Post that it isn’t changing how it stores, manages, or protects customer data and that any buyer will have to comply with applicable privacy laws.
That’s left many privacy advocates unconvinced. “Delete, delete, delete,” Sara Geoghegan, senior counsel at the Electronic Privacy Information Center, told the Washington Post. “Consumers should delete their accounts while they still can.”
The question for 85% of customers should be; "Who else has my genomic data?"https://t.co/hW2mafyctU
— MerseyTrades (@MerseyTrades) March 25, 2025The Usual SuspectsImagine not giving seven great actors/actresses a chance! #snowwhite
♬ original sound - John FergusonWhat do you think of Big Business This Week? Tell us how you really feel in this survey!
TrumplandiaThe sturm und drang of tariffs and DOGE cuts, not to mention the Signal chat memes, is taking a whack at America’s productivity, and even as the short-term outlook for inflation remains reassuringly stable, medium-term inflation risks are growing. That’s because the turmoil is making everyone apprehensive, so they indulge in pre-inflationary behavior. Economist Greg Daco at Ernst & Young calls it “preemptive inflation anxiety,” and warns that through hoarding and stockpiling and cutting back spending, it could end up creating the very inflation it fears.
Meanwhile, The Conference Board reported that its Expectations Index—based on consumers’ short-term outlook for income, business, and labor market conditions—dropped 9.6 points to 65.2, the lowest level in 12 years and well below the threshold of 80 that usually signals a recession is coming. “Consumers’ optimism about future income—which had held up quite strongly in the past few months—largely vanished, suggesting worries about the economy and labor market have started to spread into consumers’ assessments of their personal situations,” said Conference Board senior economist Stephanie Guichard.
But there are also some real issues with rising prices. A 25% tariff on imported cars announced this week will raise the price not only of the half of cars sold in the U.S. that are made or assembled abroad, but probably of every other car, because they all use foreign parts. First NAFTA, and then Trump’s rejiggered NAFTA+, called USMCA, created a nearly tariff-free zone in North America, prompting carmakers to optimize prduction across the region. That cost savings is now gone, and it would take a decade or more to build capacity to make everything at home, and that’s only if companies believe Trump’s tariffs have any staying power.
The DOGE plan to stymie the IRS might sound great to small-govenment fans, but it could bring the country close to default as early as May—instead of a previous prediction of Septemebr—if the IRS fails to collect enough taxes to keep the government running. Then the debt ceiling will have to be raised, an uncertain prospect these days. (Treasury and IRS officials say they expect a 10% drop in the amount of tax collected, down from the $5.1 trillion collected last year.)
All that uncertainty has turned corporate CFOs glum. Average optimism among chief financial officers surveyed by the Fed and Duke University dropped from a pandemic era high of 66 out of 100 to 62.1 this quarter. The index had jumped 6 points on Trump’s election. The drop appears tied to rising concerns about tariffs and trade. The CFOs now anticipate slower growth and higher prices than they did at the end of last year.
Cashing in, again: Trump just can’t quit crypto. Trump Media and Technology Group, which owns the Truth Social platform, says it’s reached agrement with Crypto.com to launch a series of exchange-traded funds with a “Made in America” focus, and will launch after getting regulatory approval later this year. Donald Trump’s still its main shareholder, and shares in the company are down more than 65% in the past year. A Trump crypto coin, launched just before his inaurugration in January, has dropped from about $72 to just over $11, and now the company that launched it, World Liberty Financial, created by Trump Middle East envoy Steve Witkoff, says it plans to launch a Trump-identified stablecoin pegged to the U.S. dollar.
Inflation: The consumer price index, a key gauge of inflation, showed that prices rose by 2.8% in February from a year earlier, driven by price relief from airfares and gas, the Labor Department said Wednesday. That was cooler than the 3% annual gain reported for January.
Get Big Business This Week in your inbox every week—and read it before everybody else! Sign up today.
Elon’s WorldX’s ad business is recovering. But it will still be smaller in 2025 than when Musk acquired Twitter, per @eMarketer estimates. pic.twitter.com/f47pff3LLI
— Jasmine Enberg (@jasmineaenberg) March 26, 2025The Short Stack
By CheddarSo you thought you could keep a secret? Well, now every secret encoded in your DNA is about to be sold to the highest bidder as the genetic testing company 23andMe goes into Chapter 11 bankruptcy protection.
Now the millions of people who paid $99 to check their DNA, hoping to learn about their ancestry, lost siblings, or hereditary disease, are wondering who’s now gonna know everything about them. Co-founder and CEO Anne Wojcicki, who took the company from nothing to a $6 billion valuation and back down to $14 million on Wednesday, said she’ll stay on as interim CEO and will mount her own third bid to buy the company, but this time the board of directors that nixed her first two lowball offers has itself resigned.
23andMe’s problems seem endemic to its business model: Faced with the realization that there’s no such thing as a recurring customer in this business (consumers have their DNA tested once, and unless they live near Chernobyl, their genetic makeup is unlikely to change), Wojcicki hoped to boost the firm’s fortunes by taking the DNA of its customers and using it to create wonder drugs. That failed—drug-making is expensive! That’s left the bank of 15 million-plus DNA samples in line to be sold.
Should 23andMe customers be worried? A company spokesperson told The Washington Post that it isn’t changing how it stores, manages, or protects customer data and that any buyer will have to comply with applicable privacy laws.
That’s left many privacy advocates unconvinced. “Delete, delete, delete,” Sara Geoghegan, senior counsel at the Electronic Privacy Information Center, told the Washington Post. “Consumers should delete their accounts while they still can.”
The question for 85% of customers should be; "Who else has my genomic data?"https://t.co/hW2mafyctU
— MerseyTrades (@MerseyTrades) March 25, 2025The Usual SuspectsImagine not giving seven great actors/actresses a chance! #snowwhite
♬ original sound - John FergusonWhat do you think of Big Business This Week? Tell us how you really feel in this survey!
TrumplandiaThe sturm und drang of tariffs and DOGE cuts, not to mention the Signal chat memes, is taking a whack at America’s productivity, and even as the short-term outlook for inflation remains reassuringly stable, medium-term inflation risks are growing. That’s because the turmoil is making everyone apprehensive, so they indulge in pre-inflationary behavior. Economist Greg Daco at Ernst & Young calls it “preemptive inflation anxiety,” and warns that through hoarding and stockpiling and cutting back spending, it could end up creating the very inflation it fears.
Meanwhile, The Conference Board reported that its Expectations Index—based on consumers’ short-term outlook for income, business, and labor market conditions—dropped 9.6 points to 65.2, the lowest level in 12 years and well below the threshold of 80 that usually signals a recession is coming. “Consumers’ optimism about future income—which had held up quite strongly in the past few months—largely vanished, suggesting worries about the economy and labor market have started to spread into consumers’ assessments of their personal situations,” said Conference Board senior economist Stephanie Guichard.
But there are also some real issues with rising prices. A 25% tariff on imported cars announced this week will raise the price not only of the half of cars sold in the U.S. that are made or assembled abroad, but probably of every other car, because they all use foreign parts. First NAFTA, and then Trump’s rejiggered NAFTA+, called USMCA, created a nearly tariff-free zone in North America, prompting carmakers to optimize prduction across the region. That cost savings is now gone, and it would take a decade or more to build capacity to make everything at home, and that’s only if companies believe Trump’s tariffs have any staying power.
The DOGE plan to stymie the IRS might sound great to small-govenment fans, but it could bring the country close to default as early as May—instead of a previous prediction of Septemebr—if the IRS fails to collect enough taxes to keep the government running. Then the debt ceiling will have to be raised, an uncertain prospect these days. (Treasury and IRS officials say they expect a 10% drop in the amount of tax collected, down from the $5.1 trillion collected last year.)
All that uncertainty has turned corporate CFOs glum. Average optimism among chief financial officers surveyed by the Fed and Duke University dropped from a pandemic era high of 66 out of 100 to 62.1 this quarter. The index had jumped 6 points on Trump’s election. The drop appears tied to rising concerns about tariffs and trade. The CFOs now anticipate slower growth and higher prices than they did at the end of last year.
Cashing in, again: Trump just can’t quit crypto. Trump Media and Technology Group, which owns the Truth Social platform, says it’s reached agrement with Crypto.com to launch a series of exchange-traded funds with a “Made in America” focus, and will launch after getting regulatory approval later this year. Donald Trump’s still its main shareholder, and shares in the company are down more than 65% in the past year. A Trump crypto coin, launched just before his inaurugration in January, has dropped from about $72 to just over $11, and now the company that launched it, World Liberty Financial, created by Trump Middle East envoy Steve Witkoff, says it plans to launch a Trump-identified stablecoin pegged to the U.S. dollar.
Inflation: The consumer price index, a key gauge of inflation, showed that prices rose by 2.8% in February from a year earlier, driven by price relief from airfares and gas, the Labor Department said Wednesday. That was cooler than the 3% annual gain reported for January.
Get Big Business This Week in your inbox every week—and read it before everybody else! Sign up today.
Elon’s WorldX’s ad business is recovering. But it will still be smaller in 2025 than when Musk acquired Twitter, per @eMarketer estimates. pic.twitter.com/f47pff3LLI
— Jasmine Enberg (@jasmineaenberg) March 26, 2025The Short Stack