Every investigation needs a starting point. Before enzymes, pathways, or genes, there is a deeper question: why does life behave the way it does at all?

In this opening episode, Medlock Holmes steps back from the bench and the bedside to examine the foundations of biochemistry itself. We explore how chemistry becomes biology, how physical laws shape living systems, and why metabolism, structure, and information are inseparable strands of the same story.

Drawing on the conceptual framework of Lehninger and the clinical orientation of Harper, this episode establishes biochemistry not as a list of reactions, but as a logic of life — one that explains health, disease, and adaptation. We examine how molecular interactions scale up to cells, tissues, and organisms, and why medicine is ultimately an applied science of biochemical balance and imbalance.

This episode sets the investigative mindset for the entire series: curiosity before memorisation, principles before pathways, and meaning before mechanism.

Think of it as arriving at the crime scene, surveying the terrain, and learning how to think like a biochemical detective.

Key Topics Explored

* Biochemistry as the bridge between chemistry, biology, and medicine

* The molecular logic underlying living systems

* Structure, energy, and information as core themes

* Why disease is best understood as disturbed biochemistry

* How clinical reasoning emerges from biochemical principles

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit drmanaankarray.substack.com/subscribe