PodBites

Biochemistry | Alcohol Metabolism


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🍐 In this episode of PodBites, Omar Luay and Abdallah Kharsa break down alcohol metabolism — following ethanol from absorption to breakdown, and explaining why this everyday substance causes such wide-ranging clinical effects.

🎙️ Tune in to explore:

  • How alcohol is absorbed, distributed, and eliminated

  • The two-step breakdown: ADH → acetaldehyde → ALDH

  • Why acetaldehyde causes flushing and hangover symptoms

  • The role of NADH excess in lactic acidosis and hypoglycemia

  • MEOS (CYP2E1) and drug–alcohol interactions

  • Genetic differences behind Asian flush syndrome

  • Chronic alcohol complications: fatty liver, cirrhosis, and neurotoxicity

  • Key clinical ties like thiamine deficiency and disulfiram

    🌟 A high-yield, clinic-linked breakdown that turns alcohol metabolism from trivia into something you can actually reason through.

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    PodBitesBy palbites2023