John Doench, associate director of the Genetic Perturbation Platform (GPP) and institute scientist at the Broad Institute, and Ruth Hanna, research associate in GPP, discuss how the CRISPR system has revolutionized studies of gene function.

BioLogic: The transformative power of CRISPR in the lab, with John Doench and Ruth Hanna

The logic behind the science: Conversations with Broad researchers exploring what they do and why they do it, from Broad Institute of MIT and Harvard.

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Joel Hirschhorn, institute member and co-director of the Metabolism Program at the Broad Institute and professor of pediatrics and genetics at Harvard Medical School and Boston Children’s Hospital, sits down with BioLogic to talk about how the research community has approached genome-wide association studies (GWAS) from concept to execution through the last decade.

BioLogic:  Ten years of perspective on GWAS, with Joel Hirschhorn

Broad Institute member Mark Daly, co-director of the Program in Medical and Population Genetics, investigator with the Stanley Center for Psychiatric Research, and chief of the Analytic and Translational Genetics Unit at Massachusetts General Hospital, describes how modern tools for analyzing the genome have empowered the study of psychiatric disorders.

BioLogic: Empowering psychiatric disease research through genetics, with Mark Daly

Genome sequencing may someday become a routine part of medical care, but questions still surround best practices for returning genetic information to patients in a way that will optimally impact their health. Geneticists Robert Green and Heidi Rehm explain their research into developing such protocols, the benefits and risks inherent in providing genetic information, and the uncertain future of legal protections against genetic discrimination.

BioLogic: The future of genome sequencing in healthcare, with Heidi Rehm and Robert Green

Nir Hacohen, an institute member at Broad, director of the Center for Cancer Immunotherapy at Massachusetts General Hospital, and an associate professor at Harvard Medical School, takes us to the intersection of cancer, immunotherapy, and autoimmune disease to explore how researchers are steering the immune system to fight tumors.

BioLogic: The transformative power of CRISPR in the lab, with John Doench and Ruth Hanna

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