A Pichia process for a recombinant protein was transferred from 10 L (Lab) to 12,000 L(GMP). Outcome: Catastrophic failure. Titer dropped 60%, and product quality degraded due toproteolysis.

A Pichia process for a recombinant protein was transferred from 10 L (Lab) to 12,000 L (GMP). Outcome: Catastrophic failure. Titer dropped 60%, and product quality degraded due to proteolysis.

Biology Does Not Scale. Physics Scales.

Welcome to Biomanufacturing &amp; Fermentation Technology, the podcast where microbes meet manufacturing and science turns into scalable reality. In each episode, we dive inside real bioprocesses. from lab-scale experiments to commercial fermenters. to unpack how products are actually made, fixed, and optimized in the real world. Expect candid conversations on fermentation failures and breakthroughs, scale-up war stories, regulatory realities, emerging technologies, and the decisions that separate a promising culture from a profitable process. Whether you are a scientist, engineer, entrepreneur, o

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Welcome to Biomanufacturing & Fermentation Technology, the podcast where microbes meet manufacturing and science turns into scalable reality. In each episode, we dive inside real bioprocesses. from lab-scale experiments to commercial fermenters. to unpack how products are actually made, fixed, and optimized in the real world. Expect candid conversations on fermentation failures and breakthroughs, scale-up war stories, regulatory realities, emerging technologies, and the decisions that separate a promising culture from a profitable process. Whether you are a scientist, engineer, entrepreneur, o

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Biology Does Not Scale. Physics Scales.

Biology Does Not Scale. Physics Scales.