Boris Birmaher MD. is Endowed Chair- Early Onset Bipolar Disease/Professor of Psychiatry at the University of Pittsburgh School of Medicine. This Podcast addresses two research questions: 1) Who among Children and Adolescents are at Risk to develop Bipolar Spectrum Disorder: 2) among patients who develop this disorder who is at risk for recurrence? This is a controlled prospective twenty year duration research study of children at higher risk because  at least one of their parents has this disorder.