Blockchain technology offers a promising solution to critical challenges in global organ transplant systems, such as lack of transparency, data tampering, and inefficiencies in organ tracking and registry management. By providing a decentralized, immutable, and auditable ledger, blockchain can enhance trust among stakeholders, ensure the integrity of consent and allocation processes, and prevent fraud or manipulation. Emerging pilot projects in countries like the U.S., Sri Lanka, and Korea have demonstrated blockchain’s potential for smart-contract-driven donor-recipient matching, real-time organ traceability, and secure cross-border coordination. However, widespread adoption faces hurdles including regulatory uncertainty, data privacy concerns, interoperability with legacy systems, and governance complexities. Continued interdisciplinary collaboration, regulatory engagement, and pilot testing are essential to realize blockchain’s transformative potential in making organ donation systems more secure, transparent, and globally connected.