This podcast was created using NotebookLM.

This podcast explores the claim that repeated short-acting nerve blocks can reset central sensitization in chronic pain. Dr. Glenn Clark argues that this idea is unlikely due to the complex neurobiological changes involved in established chronic pain. Research suggests that while nerve blocks can prevent sensitization, they are less effective at reversing it because central sensitization involves receptor modifications, genetic changes, structural remodeling, and glial activation, which are not easily reversed by temporary input blockage.