This episode dives into the critical role of blood cultures in diagnosing bacteremia, covering everything from indications and collection techniques to laboratory analysis and result interpretation, all based on the comprehensive UpToDate article on this topic. Learn when to order blood cultures, how to minimize contamination, and how to distinguish clinically significant organisms from contaminants, with practical guidance for follow-up testing to monitor treatment. The podcast occasionally concludes key subtopics with "if you can’t remember everything, remember this," offering concise takeaways to solidify your understanding. Perfect for residents seeking to master this essential diagnostic tool.