Vidcast:  https://youtu.be/lnfpbeZ7pqU

 

Victims of Traumatic Brain Injuries, TBI for short, have a 23 to 63 fold higher risk of death during the ensuing 6 months when they have high levels of two protein biomarkers circulating in their bloodstreams on the day of injury.  This conclusion stems from a collaborative study from the University of Michigan, UC-San Francisco, and the University of Pennsylvania.

 

The researchers studied 1700 patients with TBI and measured their circulating levels of two proteins, GFAP and UCH-L1 as they were admitted to the hospital.  The levels of these proteins were compared with the occurrence of patient mortality within 6 months post-injury.   Those with the highest vs. the lowest GFAP values had a 23 times higher risk of death while those with the highest vs. the lowest UCH-L1 values had a 63 times higher risk of death.

 

This prospective data is invaluable for setting realistic family expectations for patient recovery after these devastating episodes of head trauma.

 

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(22)00256-3/fulltext

 

#tbi #gfap #uchl1 #mortality

tbi, gfap, uchl1, mortality