Bob Feller was born and raised in Van Meter, Iowa. His father ran the family farm, and his mother was a registered nurse and a teacher. Feller credited his arm strength and ball speed to milking cows, picking corn, and baling hay. He recalled his childhood fondly: "What kid wouldn't enjoy the life I led in Iowa? Baseball and farming, and I had the best of both worlds." The family's farm is on the National Register of Historic Places.

Feller's father built a baseball diamond on the farm that he named "Oak View Park", then recruited his son and others to play for a team he named The Oakviews.

Feller joined the Cleveland Indians without having played in the minors. He spent his entire career of 18 years with the Indians, being one of "The Big Four" Indians pitching rotation in the 1950s, along with Bob Lemon, Early Wynn and Mike Garcia. He ended his career with 266 victories and 2,581 strikeouts and led the American League in strikeouts seven times and bases on balls four times. His fastball was nicknamed "the Van Meter Heater." He pitched three no-hit games and shares the major league record with 12 one-hitters. Feller was the first pitcher to win 20 or more games before the age of 21. He was elected to the Baseball Hall of Fame in 1962, his first year of eligibility. When he was 17 years of age, he struck out 17 batters; he and Kerry Wood are the only two players ever to strike out their age.

When Feller retired in 1956, he held the major league record for most walks in a career (1,764), and for most hit batsmen. He still holds the 20th century record for most walks in a season (208 in 1938).

He spoke to students at the 1990 Academy of Achievement Summit in Chicago.