Metastatic bone disease (MBD), a condition where cancer spreads to the bones. They address its epidemiology and impact, highlighting common primary cancers that metastasize to bone and the resulting pain and bone weakness, which can lead to pathological fractures. The texts also detail diagnostic methods and a variety of treatment strategies, including medical therapies such as bisphosphonates and denosumab, various radiation therapies, and a comprehensive overview of surgical interventions for different bone locations, all aimed at alleviating pain and restoring function. The importance of a multidisciplinary approach to managing MBD is emphasized throughout these orthopaedic and oncology-focused materials.