Our invited speaker, Dr Eric Sigmund, will take us on a journey of discovery exploring the basic principles of image acquisition using diffusion weighted ((DWI) MR imaging and how the technique applies to autoimmune conditions affecting the muscles of the pelvis and thighs. Eric and I work together along with a group of investigators including Dr Steven Baete at the NYU Center for Biomedical Imaging developing MEDITATE. This is a sequence that uses DWI as a probe for assessment of muscle microstructure during exercise activation. The listener will find this episode the right combination of being informative, but yet entertaining. Enjoy!