Episode 1 of Brain Explained explores Alzheimer's Disease research with (the now) Dr Hemant Mistry of the University of Sheffield. Hermant's work looks at the role of brain cholesterol in the development of Alzheimer's Disease.  We discuss his work on post-mortem brain tissue, cell cultures, impact of oxidative stress on neurons and more. We also discuss careers which is particularly useful for those wanting to break into the field of neuroscience. Hemant's contact info: [email protected]