Welcome to the 34th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with first author Dr Lorenzo Pini of the Brain article entitled: Brain connectivity as a new target for Alzheimer's disease therapy?

We discuss a fascinating review into the literature examing brain connectivity in Alzheimer's disease as a biomarker for symptom progression, diagnosis and monitoring response to treatment. Further, they discuss whether brain stimulation to target connectivity may have therapeutic opportunities. The article also features a discussion around digital twins to facilitate Alzheimer's research - well worth a read!

Check out the full article on the Brain website as part of the Feb 2026 issue: https://doi.org/10.1093/brain/awaf404

This episode was co-hosted, edited and produced by Michael and Adam Handel, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.