Brain Damage is a 1988 American comedy horror film written and directed by Frank Henenlotter.

It stars Rick Hearst in his debut acting role as Brian, a young man who becomes acquainted with a talking parasite known as Aylmer (voiced by John Zacherle) that injects him with an addictive fluid that causes euphoric hallucinations; in return, Aylmer demands that Brian allow him to feed on the brains of other humans.