What's the optimal ApoB level to reduce Alzheimer’s risk? Is lifestyle or genetics more important? And what does a pTau217 result actually mean for your brain health?

In this Brain Health Q&A, I answer your questions about ApoB, APOE2, dementia prevention, blood-based biomarkers, and what the science actually says right now.

Missed the first video? Check it out here: https://youtu.be/y8vkJE_Zy7A

Topics include:
• How low I think ApoB should ideally be for brain health (and what matters more!)
• How to think about lifestyle vs genetic risk like APOE4
• What current guidelines recommend for pTau217 and its limitations
• What I’d personally focus on for long-term brain protection (and teasers for our upcoming videos in the series)

As a vascular surgeon specializing in cardiometabolic prevention, I spent years treating the downstream consequences of vascular disease after the damage was already done. Brain health is no different. Prevention matters most before symptoms start.

The brain is not magically separate from the rest of the body. Blood vessels, inflammation, metabolic health, sleep, exercise, and genetics all interact over decades. So let’s talk about how to think about that risk honestly — and practically.

👇 Drop your questions in the comments for the next Q&A.

Sign up for more information on my own practice here: https://corsighthealth.com/

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🧬 About Dr. Lily Johnston
  
Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.
  
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