Dr. Deepak Sarpal is Assistant Professor of Psychiatry/Medical Director of Services for Treatment of Early Psychosis at WPH. This Podcast focuses upon Clozapine, a very valuable but underused treatment for refractory schizophrenia, also brain science involving functional imaging associated with patient improvement on anti-psychotic drugs. Findings include brain pre-frontal cortex connectivity and synchronization of function with brain striatum, limbic system structures, Globus Pallidus.