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Anthropologist Michael Winkelman, PhD, joins Dr. Dennis McKenna on the Brainforest Café to compare shamanic and psychedelic healing practices across Mexico, Peru, Colombia, and North America. Winkelman spent forty years researching shamanism, psychedelics, and altered states, and his new edited volume gathers case studies of mushroom, peyote, San Pedro, morning glory, and ayahuasca traditions under a single framework. What emerges is a pattern too consistent to be coincidence: fasting, sexual abstinence, restricted diet, an overnight ceremony, family and community present, songs at the center, and a long integration period built around dreams and behavior change. His argument is that these are not cultural decorations around the chemistry. They are the vessel the chemistry requires, and modern clinical research has quietly discarded most of them.
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Michael Winkelman is an ASU anthropologist and leading scholar of shamanism and psychedelics, with 40 years of cross-cultural research and editor of the Handbook of Entheogenic Healing (2025).
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In this episode of the Brainforest Café, Dr. Dennis McKenna sits down with Kat Maier, a registered herbalist and physician's assistant who has practiced for more than forty years and wrote the award-winning book Energetic Herbalism. Together they explore what modern medicine loses when it separates the body from spirit: how energetic traditions read the body as a living landscape (hot or cold, damp or dry, tense or relaxed), why context can matter as much as chemistry, and where the psychedelic renaissance fits into a much older understanding of plants as medicine for the soul. It is a warm, rigorous conversation about healing, reciprocity, and our estrangement from nature.
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For nearly a century, reports of a mysterious psychoactive bolete have puzzled ethnomycologists and anthropologists alike. From the 1930s reports of "mushroom madness" in the highlands of Papua New Guinea, which drew the curiosity of R. Gordon Wasson, Roger Heim, and Albert Hofmann, to modern Yunnan, China, where accidental poisonings from undercooked culinary mushrooms cause people to reliably see visions of tiny, colorfully dressed "little people."
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Colin is a Bay Area California native whose research focuses on unravelling the ethnomycological mystery of psychoactive bolete mushrooms. With a lifelong interest and undergraduate degree in astronomy before changing his studies to the ethnobiology of psychoactive substances, Colin has always felt attracted to explore the mind-bending wonders of nature. In his free time, he enjoys engaging in just about any outdoor activity with friends, most of all foraging for mushrooms.
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Dennis McKenna sits down with scholar, lawyer, and philosopher Tam Hunt (UC Santa Barbara’s META Lab) to dive deep into the mysteries of consciousness, psychedelics, and the existential crossroads of artificial intelligence.
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Jonathan Dickinson, CEO and co-founder of Ambio Life Sciences and author of Ibogaine and the Bicameral Mind, returns to the Brainforest Café for part two of his conversation with Dr. Dennis McKenna. Where part one followed the personal journey, this one goes into the machinery: what ibogaine is actually doing to the mind and to the cell.
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Jonathan Dickinson, co-founder and CEO of Ambio Life Sciences and
A Mexico-licensed psychologist and former executive director of
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Jonathan Dickinson, co-founder and CEO of Ambio Life Sciences and
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Jonathan Dickinson, a Mexico-licensed psychologist and former executive director of the Global Ibogaine Therapy Alliance, Jonathan helped develop the field's foundational safety guidelines and completed the first
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What if the future of ayahuasca isn’t in the hype cycle, but in safety, tradition, and real transformation? In this conversation, Sam Believ and Dennis McKenna explore Colombia’s overlooked ayahuasca lineage, the importance of set and setting, and why plant medicine may hold a key to healing both people and culture.
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Sam Believ is the founder of LaWayra Ayahuasca Retreat and host of the Ayahuasca Podcast.
A former offshore engineer turned modern bridge-builder, Sam is dedicated to making traditional Amazonian medicine accessible, safe, and grounded for the modern world.
He build LaWayra - currently the biggest Ayahuasca retreat in Colombia, while raising 3 small kids all in 2 foreign languages and without any business background.
At LaWayra he has guided close to 3000 people through their Ayahuasca experience.
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In this conversation, Patricia Eastman and Dennis McKenna explore the deeper meaning of psychedelic healing through the lens of ancestral wisdom, initiation, and nature-based practice. Patricia shares the story behind her book Seeding Consciousness and her vision for Hu Azores, a retreat center in Portugal designed as a healing space that integrates architecture, ritual, and circadian-aware design. The discussion moves beyond symptom treatment and into a bigger question: how psychedelics can support creativity, integration, and a more connected human experience.
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Patricia Eastman, Initiated is a Bwiti Traditional Practitioner for over 11 years and founder of the nonprofit Ancestral Heart, has curated transformative retreats with plant medicines worldwide as well as facilitated the psychospiritual program with ibogaine and 5-MeO-DMT at Crossroads Treatment Center in Mexico. A renowned speaker, artist, and writer, Eastman has engaged with audiences at Stanford University, the World Economic Forum, and on Gaia TV's Psychedelica. Eastman is the author of Seeding Consciousness: Plant Medicine, Ancestral Wisdom, and Psychedelic Initiation.
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In 2003, Carlos Tanner woke up in his car underwater, having blacked out behind the wheel and driven into a river. Deep in an opiate addiction, he went to the Amazon to save his own life. What he found there became his life's work.
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In this episode of the Brainforest Café, Dennis McKenna sits down with medicinal chemist Matt Metcalf to explore a genuinely strange frontier: testing drugs in pea seedlings and the touch-sensitive Mimosa pudica instead of in mice. Along the way they circle the question that started it all, why the opium poppy spends so much energy making opioids at all, and what those molecules might be doing inside a plant that has no nerves.
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Matthew Metcalf is a neuroscientist with a background in the medicinal chemistry and pharmacology of opioids and cannabinoids as analgesic drugs. He is an assistant professor of Medicinal Chemistry at the Massachusetts College of Pharmacy and Health Sciences University (MCPHS) School of Pharmacy - Worcester.
His current research focuses on the development of New Approach Methodologies (NAMs, sometimes called Non-Animal Models) drug tests to limit the use of animals used in drug testing.
His current work focuses on the use of living plants as the biological organisms to replace animal models used as drug tests.
Outside of his research he is passionate about auroras and timelapse photography.
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