Penn Talks Science

Breaking Down "A Misfolding Misfortune" A Sci-Comm inspired D&D Module


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Welcome science adventurers!


In Episode 3 of this mini-series, we break down our playthrough of PSPDG’s SciComm Dungeons & Dragons adventure on neurodegenerative disease, “A Misfolding Misfortune,” written by Dimitris Boufidis, Freddy S. Purnell, Tammy Ray, David Sidibe, and Amanda N. Weiss.

Join our DM, Amanda Weiss, and our players Diego Mendez, Gabriel Vega-Bellido, Miles Arnett, and Joseph McGaunn as they discuss the ideas and scientific concepts behind A Misfolding Misfortune, and how our understanding of neurodegenerative disorders helped inspire this adventure. The TTRPG team set out to make this module both fun and educational—and accessible for anyone interested in giving it a try.


This module is available for free here: https://www.pspdg.com/ttrpgs/2025/1/7/a-misfolding-misfortune-dampd-5e-adventure-about-neurodegenerative-disease


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Penn Talks ScienceBy Penn Science Policy and Diplomacy Group


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