In this episode of 'My Sister is a Karen', Jennifer and Karen discuss the 'We Do Not Care' Club, a movement for women experiencing menopause and perimenopause. They share personal anecdotes about their experiences with health, hormones, and the lack of awareness surrounding menopause. The sisters emphasize the importance of breaking the silence on these topics and advocate for better research and communication about women's health issues. They also touch on the impact of COVID-19 on mental health and the need for generational conversations about menopause.