PACUPod: Oncology

Brentuximab vedotin plus chemotherapy for the treatment of frontline systemic anaplastic large cell lymphoma subgroup analysis of the ECHELON2 study at 5 years followup summary

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{
"episode_title": "ECHELON-2 5-Year Follow-Up: Brentuximab Vedotin Plus CHP in Frontline sALCL",
"episode_description": "In this PACUPod episode, Britany and Seth dissect the five-year subgroup analysis of the ECHELON-2 trial focused on frontline systemic anaplastic large cell lymphoma (sALCL). They compare brentuximab vedotin plus CHP (BV+CHP) against CHOP in untreated CD30-positive PTCL, highlighting long-term efficacy and safety. Key findings include progression-free survival not reached with BV+CHP versus 29.4 months with CHOP (HR 0.71, P=0.011), five-year overall survival of 70.1% vs 60.9%, and higher complete remission rates (67% vs 50%). The discussion covers tolerability (noting higher—but generally reversible—peripheral neuropathy with BV+CHP and lower febrile neutropenia), the rationale for omitting vincristine to reduce neurotoxicity, mechanistic insights into CD30 targeting and MMAE delivery, dosing (1.8 mg/kg every 3 weeks for 6–8 cycles), and practical implications including NCCN category 1 frontline recommendation for sALCL. The hosts also address patient selection, real-world applicability, potential roles for consolidative stem cell transplant, and directions for future research.",
"keywords_json": {
"keywords": [
"ECHELON-2",
"brentuximab vedotin",
"CHP",
"CHOP",
"frontline therapy",
"systemic anaplastic large cell lymphoma",
"sALCL",
"CD30-positive",
"ALK-positive",
"ALK-negative",
"progression-free survival",
"overall survival",
"complete remission",
"hazard ratio",
"five-year follow-up",
"peripheral neuropathy",
"febrile neutropenia",
"neurotoxicity",
"dosing 1.8 mg/kg",
"every 3 weeks",
"six to eight cycles",
"vincristine omission",
"antibody-drug conjugate",
"monomethyl auristatin E",
"NCCN category 1",
"real-world data",
"Sasaki 2020",
"Horwitz meta-analysis",
"consolidative stem
...more
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PACUPod: OncologyBy Pharmacy & Acute Care University