This release contains only the music track from Base by Base Episode 12.

Song title: Bridge of Iron and Light
Original Base by Base episode: 12: MUTYH's allosteric [4Fe-4S] network

Article metadata:
Article title: Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair
Journal: Nature Communications
DOI: 10.1038/s41467-025-58361-w
Reference: Trasviña-Arenas CH, Dissanayake UC, Tamayo N, et al. Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair. Nature Communications. 2025;16:3596. doi:10.1038/s41467-025-58361-w

Lyrics:
Verse 1
Under cold white lights and steady hands,
I trace the scratch across the strands,
A single letter out of place,
A quiet threat inside the lace.

Pre-Chorus
There’s a spark in the metal, a pulse in the dark,
A hidden route for a message to arc,
From iron-bound silence to acid and flame,
One tiny switch that remembers the name.

Chorus
Hold the line, let it carry the news,
Iron to the heart where the wrong gets removed,
If the bridge breaks, the engine still turns,
But the fix won’t land and the damage returns.
Hold the line—feel the signal run true,
From the cluster to the cut, back to me and you.

Verse 2
Some changes don’t shatter the shape you see,
They keep their grip, they still bind clean,
But the whisper between “here” and “go”
Falls apart where the soft bonds flow.

Bridge
Not every failure looks like a fall,
Sometimes it’s silent, standing tall,
A proton misplaced, a step delayed,
A cure in the map of the paths we made.

Final Chorus
Hold the line, let it carry the news,
Iron to the heart where the wrong gets removed,
If the bridge breaks, the engine still turns,
But the fix won’t land and the damage returns.
Hold the line—now we finally see,
How a network of touch sets the faithful free.