Point of Care CME is learning that is practice-based and takes place in support of specific patient care. Various devices, including computers or internet devices, assist the physician, usually as part of a clinical decision-making tool to reference evidenced based sources and apply a recommendation. Host Lawrence Sherman and Dr. Richard A. Berger, dean of the Mayo School of Continuous Professional Development at the Mayo Clinic and chair of the Accreditation Review Committee of the Accreditation Council for Continuing Medical Education (ACCME), discuss breakthroughs, trends and the future of Point of Care CME.