From controlling libido to epilepsy, bromides surged in popularity but experienced an equally precipitous decline in 19th century medicine. As the paradigm of disease explanation progressed from humors to pathology, bromides established a therapeutic foothold during this revolutionary period. What followed, however, were urban myths and consequences of toxicological significance. Used so ubiquitously, bromides earned a place in the colloquial lexicon as remarks repeated with such frequency that they become cliché or trite. Yet, this exploration on bromism promises to be anything but.