Simini Boards Cast

Bug Wars III: Combo Killers — Synergy, Antagonism, and When It All Goes Wrong


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You added a second antibiotic to play it safe… and sabotaged your treatment.

In this episode, we unpack why combining antimicrobials can be a powerful strategy — or a clinical disaster.

🔍 You’ll learn:

  • The difference between synergy, additive effects, and antagonism
  • Why static + cidal combos can cancel each other out
  • Which combinations actually work (and why)
  • When to combine, when to de-escalate, and when to walk away
  • Toxicity overlap, PK/PD interactions, and board-level traps to avoid

💡 Includes a board-style question + flashcard-style recap.

🎧 Built for surgical residents. 
 Feedback or requests? Carl Damiani ([email protected])

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Simini Boards CastBy Simini Podcasts