In this episode of FoGCast, we sit down with Dr. Heidi Rehm, Chief Genomics Officer at Massachusetts General Hospital and co-director of the Broad Institute’s Center for Mendelian Genomics. From her early fascination with puzzles and biology to leading groundbreaking data-sharing efforts like ClinGen and ClinVar, Heidi discusses the evolution of genomics, the importance of collaboration, and the global push toward more equitable healthcare. We also explore the challenges of public trust, diversity in genetic data, and how genomics is poised to transform primary care.