Dr. George Siberry, former Chief Medical Officer in USAID’s Office of HIV/AIDS, has spent his career at the heart of the global fight against HIV. A pediatrician by training, George began his journey translating for children with HIV in Baltimore and went on to help shape the President’s Emergency Plan for AIDS Relief (PEPFAR) approach to prevention, treatment, and care around the world. In this conversation, he reflects on the evolution of HIV and the programs created to fight it—from stigma and isolation to people-centered health—and what it takes to build systems that strengthen communities and improve health outcomes rather than treating diseases in isolation.

As USAID’s dismantling leaves critical partnerships fractured and PEPFAR’s future uncertain, George speaks candidly about grief, loss, and the work of rebuilding trust. He makes a powerful case for why America’s investments in global health were never just acts of charity—they were expressions of diplomacy, innovation, and shared humanity.

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