This paper argues for the crucial role of open science ecosystems, using the NIH HEAL Initiative as a case study, in addressing complex public health issues like the opioid epidemic and chronic pain management. It highlights the challenges of data inaccessibility and advocates for building community around data through transparent research methods, open access, collaborative approaches, and standardized data elements. The paper emphasizes the need to shift research culture towards active data sharing, embrace data standards (FAIR principles), and leverage AI and advanced data science methods to accelerate discovery and improve outcomes for individuals affected by chronic pain and addiction.