In this inspiring episode of Life of a CISO, Dr. Eric Cole sits down with Zachary Lewis, Chief Information Security Officer at the University of Health Sciences and Pharmacy in St. Louis. With over five years in the CISO seat and a career that spans startups, coal plants, and higher education, Zach shares his unique journey from sysadmin to security leader. This episode offers a front-row seat into what it really takes to pivot into cybersecurity leadership—especially when you're coming from the IT side. Zach breaks down how to make the transition, why leadership trumps deep technical skills at the CISO level, and how to build credibility even when you don’t have decades of cyber experience under your belt.

But this conversation goes beyond resumes and frameworks. Zach and Dr. Cole dig deep into the realities of leading during a global crisis—Zach took his role just weeks before COVID—and how a ransomware incident became a turning point in proving the strength of his security program. For aspiring CISOs and current security leaders alike, this episode is full of wisdom on how to lead with calm, build board-level trust, and turn unexpected challenges into defining moments. Whether you’re just starting out or looking to sharpen your executive edge, Zach’s story is a blueprint worth studying.