Jackie Shaw is building OneSkin's people infrastructure from the ground up as their first in-house people leader, navigating the unique challenge of scaling culture across a 40-person remote-first team where 85-90% work remotely while their R&D scientists operate in San Francisco labs. In a longevity skincare company founded by four PhD scientists, Jackie bridges the gap between highly technical research teams and business operations, creating systems that maintain psychological safety in a high-stakes environment where experimental failures can cost millions. Her approach prioritizes proactive infrastructure building over firefighting, embedding wellness as a core career strategy rather than a perk, and using strategic context-switching to address the constantly evolving needs of a scaling startup.