This release contains only the music track from Base by Base Episode 1.

Song title: Buried Signals, Clearer Calls
Original Base by Base episode: 1: Structure-informed computational evidence sharpens BRCA1 missense classification

Article metadata:
Article title: ACMG/AMP interpretation of BRCA1 missense variants: Structure-informed scores add evidence strength granularity to the PP3/BP4 computational evidence
Journal: The American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2024.12.011
Reference: Ramadane-Morchadi L., Rotenberg N., Esteban-Sánchez A., et al., ACMG/AMP interpretation of BRCA1 missense variants: Structure-informed scores add evidence strength granularity to the PP3/BP4 computational evidence. The American Journal of Human Genetics 112, 993–1002 (2025). https://doi.org/10.1016/j.ajhg.2024.12.011

Lyrics:
Verse 1
On bright screens, a single letter turns the tide
A quiet swap in BRCA1, hard to read inside
We hold the rulebook up against the unknown
Looking for a sign in the protein’s bones

Pre-Chorus
Not every number tells the whole story straight
Some land in the gray where the stakes feel late
So we map the fold, we test the weight
Till the evidence learns to calibrate

Chorus
Give me structure, give me light
Turn “maybe” into black-and-white
When the score runs high and the fold breaks tight
We can call it strong, we can name what’s right
Buried signals, clearer calls
From hidden cores to hospital halls

Verse 2
AlphaMissense draws the line with a steadier hand
Fewer empty answers in the shifting sand
DDG feels the strain when the scaffold bends
And solvent tells where “benign” begins

Bridge
If the residue’s buried, BP4 can speak
If it’s out in the open, the calm gets weak
Cutoffs like compass points in a storm
Granular proof in a human form

Final Chorus
Give me structure, give me light
Turn “maybe” into black-and-white
When the score runs high and the fold breaks tight
We can call it strong, we can name what’s right
Buried signals, clearer calls
One clearer verdict can change it all