After Barrie Craig went off the air, Gargan continued to occasionally host Family Theater. He also made films Miracle in The Rain and The Rawhide Years. He starred on the west-coast stage in a version of The Desperate Hours for Randy Hale and went to Europe to film thirty-nine episodes of The New Adventures of Martin Kane for Ziv Productions.

In 1960 Hale was set to cast Gargan on stage in The Best Man, but a bout with Laryngitis forced Gargan to get some tests on his throat done.

It was throat cancer. Doctors were forced to remove his larynx On November 10th, 1960. A breathing stoma was cut into the bottom of his throat. A man whose voice made him famous no longer had one.

For a time he was depressed. Friends Bing Crosby, Dennis Day, Phil Harris, Alice Faye, and many others came by. It helped. Gargan couldn’t bear the thought of not speaking again. He made his first vocal lesson through The American Cancer Society in January of 1961.

It took him more than a year, but by the following February he was making progress. The ACS was looking for a Southern California Vice Chairman for their 1962 drive. Gargan agreed to serve.

In 1963, he met President Kennedy. He had a meeting set with the President for November 23rd. It was one that President Kennedy never made it to.

By then his brother Ed was ill with diabetes and emphysema. He passed away in 1964. That year, Gargan was hired by the ACS for their full-time national staff.

Within three years, Gargan mastered esophageal speech. He wouldn’t use a vocal amplifier and worked tirelessly to be able to speak in both low and high tones.

Bill thanked his wife Mary for refusing to let him give up and for his faith that kept him asking why. That’s what he titled his autobiography, Why Me?

By then he knew the answer. Bill Gargan spent the next two decades raising money, awareness, and the spirits of fellow cancer patients around the country.

On February 16th, 1979 while on a flight between New York City and San Diego following a tour lecturing for the ACS, Gargan suffered a fatal heart attack. He was seventy-three. William Dennis Gargan is buried at Holy Cross Cemetery in San Diego, California.