This release contains only the music track from Base by Base Episode 313.

Song title: Calibrate the Signal
Original Base by Base episode: 313: Integrating Polygenic Risk Scores and Social Determinants of Health across Populations
Original episode link: https://basebybase.com/episodes/polygenic-risk-sdoh-harmonization

Article metadata:
Article title: Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in research
Journal: The American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2026.02.007
Reference: Cromer SJ, Cobran EK, Iyer HS, Hysong MR, Vargas LB, Smith JL, Konigsberg IR, Bogumil D, Glover L, King G, PRIMED Consortium SDoH Working Group, Lange LA, Patel A, Wojcik G, Raffield L, Conti DV, et al. Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in research. The American Journal of Human Genetics. 2026;113:1–25. https://doi.org/10.1016/j.ajhg.2026.02.007

Lyrics:
Verse 1
On bright screens we draw the future in lines,
A thousand tiny letters trying to speak in time.
But the map that fits one skyline in the rain,
Can miss the next door heart, call it “risk” in vain.

Pre-Chorus
When the dataset tilts, the compass drifts,
And silence in the variables changes what it gives.
So we ask the hard questions, name what we can’t see,
Build a fairer measure from biology and streets.

Chorus
Calibrate the signal, don’t crown it as fate,
Genes are a rhythm, not a locked gate.
Tune it with the context, let the real world in,
So prediction becomes a promise—not a spin.

Verse 2
Alleles shift their patterns, links break and re-tie,
Different threads of history under the same sky.
And where you live, what you face, what care you can reach,
Can bend the odds like gravity, reshaping what we teach.

Bridge
Harmonize the questions, align the way we count,
Test the cause and pathways, trace what they amount.
If we share the spotlight, widen every lens,
We can stop old bias from wearing science’s name again.

Final Chorus
Calibrate the signal, don’t crown it as fate,
Genes are a rhythm, not a locked gate.
Tune it with the context, let the real world in,
Make it travel farther—let equity begin.