ADHD stimulants are among the most effective drugs in psychiatry, but they raise heart rate and blood pressure — a serious problem for a growing patient population. This episode explores whether we can decouple cognitive benefits from cardiac side effects. We delve into the molecular dance of dopamine and norepinephrine, the stubborn homology of their transporters, and why designing a cleaner molecule is harder than it sounds. From the efficacy gap between stimulants and non-stimulants to the "Goldilocks polypharmacology" of the future, we examine if a scalpel can ever replace the sledgehammer.