Welcome to the 29th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.

This episode features a discussion with first author of the Brain article entitled: Distinct transcriptional changes distinguish efficient and poor remyelination in multiple sclerosis

We are joined by Alida Chen for an interesting discussion into detecting transcriptional changes that may identify efficient remyelination in multiple sclerosis. Using brain bank donor tissue, the authors examine donors who show efficient remyelination compared with those who had poorly remyelinating lesions. They discuss interesting findings around the epithelial–mesenchymal transition pathway as well as the MTORC1 signalling pathway. Further, the team discusses how these findings may translate to in vivo understanding of efficient remyelination in patients with MS as well as other experimental models that may help elucidate this.

Check out the full article on the Brain website as part of the June 2025 issue: https://doi.org/10.1093/brain/awae414

This episode was co-hosted, edited and produced by Chaitra Sathyaprakash and Andreas Thermistocleous, edited and produced by Chaitra and Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.