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Carbidopa/levodopa
Trade NameSinemet
IndicationParkinson's disease
ActionLevodopa is converted to dopamine and works as a neurotransmitter, carbidopa prevents the destruction of levodopa allowing it to cross the blood brain barrier
Therapeutic ClassAntiparkinson agent
Pharmacologic ClassDopamine Agonist
Nursing Considerations• May cause orthostatic hypotension • May cause dark urine • Weeks to months to take effect • Do not use with MAOIs • Do not use with glaucoma, melanoma • Assess for parkinsonian symptoms • Instruct patient to take as directed
By Jon Haws, RN CCRN Alumnus4.4
158158 ratings
Carbidopa/levodopa
Trade NameSinemet
IndicationParkinson's disease
ActionLevodopa is converted to dopamine and works as a neurotransmitter, carbidopa prevents the destruction of levodopa allowing it to cross the blood brain barrier
Therapeutic ClassAntiparkinson agent
Pharmacologic ClassDopamine Agonist
Nursing Considerations• May cause orthostatic hypotension • May cause dark urine • Weeks to months to take effect • Do not use with MAOIs • Do not use with glaucoma, melanoma • Assess for parkinsonian symptoms • Instruct patient to take as directed

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