Mike and Nate start with a lighthearted discussion about their on-air personas and Cinco de Mayo before celebrating Mosen Madawi's release from ICE detention. They examine the impact of Trump's tariffs on the economy, particularly the Port of Los Angeles's 25% decrease in cargo ships and its ripple effects on jobs. The conversation covers Florida's controversial ban on water fluoridation, Vinay Prasad's concerning appointment as FDA administrator, and RFK Jr.'s questionable stance on vaccine trials. They critique the Democratic Party's approach to immigration policy and discuss the Supreme Court's decision to allow the transgender military ban. The episode concludes with analysis of an AI-generated controversy involving Trump portrayed as the Pope.