In an attempt to further my understanding of some of the methods used in research Gavin Denton (@dentongavin) and I had a discussion about the SepsisPAM trial below. This is a new approach on the podcast and one which I hope people will find useful. We go through the article using a systematic approach, and you can find the links to the CASP tool we use here. We also refer to CEBM.net here. We also try to stop to discuss any terminology which we were not too familiar with or needs clarification to help others understand it.

We would be really grateful for any feedback to let us know what you think.

Could we do it differently? A different format? Let me know via the speak pipe link to the side of this page.

High versus Low Blood-Pressure Target in Patients with Septic Shock

Pierre Asfar, M.D., Ph.D., Ferhat Meziani, M.D., Ph.D., Jean-François Hamel, M.D., Fabien Grelon, M.D., Bruno Megarbane, M.D., Ph.D., Nadia Anguel, M.D., Jean-Paul Mira, M.D., Ph.D., Pierre-François Dequin, M.D., Ph.D., Soizic Gergaud, M.D., Nicolas Weiss, M.D., Ph.D., François Legay, M.D.,

N Engl J Med 2014; 370:1583-1593April 24, 2014DOI: 10.1056/NEJMoa1312173