The Center for Disease Control and Prevention (CDC) recently issued new Hepatitis C virus (HCV) screening recommendations for all persons in the United States born between 1945 and 1965.  Almost at the same time, the United States Preventive Services Task Force (USPSTF) issued its recommendation to screen adults at high risk for HCV. A commentary in the March of Gastroenterology takes an overview of these differing recommendations and offers take-home messages for readers. Dr. Kuemmerle speaks to commentary co-author Dr. Fasiha Kanwal of Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas; Plus, a rundown of top stories from this month's issue of GI and Hepatology News.