Cell-free DNA testing in cancer, where circulating free DNA from tumours is analysed via a blood test, is transforming cancer diagnosis and management.

How are these advances being integrated into clinical practice, and what are the latest updates for pathologists involved in cancer care?

In this episode of The Pathology Report, host Dr Donna Lenghaus is joined by Professor Ronald Trent, genetic pathologist at the Royal Prince Alfred Hospital, and Associate Professor Mirette Saad, chemical pathologist and national director of molecular genetics at Australian Clinical Labs, to discuss the current state of cell-free DNA testing, and where this rapidly-evolving field is heading to next.

They explore:

• the application of cell-free DNA testing vs solid tissue biopsies in detecting somatic mutations
• how these tests can be used as a minimally invasive method for detecting cancer, and for the real-time monitoring of genomic changes in tumours.
• access considerations, including benefits for regional patients and those too unwell to undergo surgery, as well as barriers associated with cost and self-funding
• challenges around the lack of standardisation across laboratories, and heterogeneity in populations
• the need for greater collaboration between pathologists and clinicians to explore how these tests can be advantageous to the patient
• the application and possibility of using cell-free DNA testing as a screening tool for cancer, including ethical considerations.

This episode offers valuable insights and essential information for pathologists and clinicians involved in cancer prevention, treatment, and management.

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