SUMMARY: Drs. Jeremy Omoro and Okemwa present a rare case of Cerebral Plasmacytoma in a 65 year old female with HA and Left parietal swelling and a progressive course of neurological involvement. A bony mass was seen externally involving the bone, but the neoplasm extended into the brain parenchyma. At surgery hyperostosis of the skull was found from a lesion in the brain, a biochemical bone growth related to the tumor. . After a surprise diagnosis was found not to be a meningioma, a diagnosis of plasmacytoma was made histologically and a treatment plan was developed. How would you manage this case from initial presentation to diagnosis and treatment? What would you do with the bone? How is it treated.The authors, with Dr. Okemwa, a pathologist, provide the details and literature review of this pathology. Interesting and Rare case. 32 minutes. (JIA)