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CGRP – a Key Molecule in Primary Headaches – Lars Edvinsson
Prof. Lars Edvinsson showed the audience how calcitonin gene-related peptide (CGRP) gradually became one of the most important molecules in primary headaches. From its discovery in the early 1980s to its role as an important target for novel specific anti-migraine drugs.
1. Edvinsson L et al. Brain Res Rev 2005;48:438-468.
2. Markowitz S et al. J Neurosci 1987;7:4129-4136.
3. Goldstein DJ et al. Cephalalgia 1997;17:785-790.
4. Amara SG et al. Nature 1982;298:240-244.
5. Rosenfeld MG et al. Science 1984;225:1315-1320.
6. Edvinsson L et al. Trends Neurosci 1985;8:126-131.
7. Uddman R et al. Neurosci Lett 1985;62:131-136.
8. McCulloch J et al. PNAS 1986;83:5731-5735.
9. Edvinsson L et al. Pharmacol Toxicol 2001;86:65-73.
10. Edvinsson L et al. Br J Pharmacol 1990;100:312-318.
11. Edvinsson L et al. Cephalalgia 1995;15:272-276.
12. Goadsby PJ et al. Ann Neurol 1988;23:193-196.
13. Edvinsson L et al. Neurotherapeutics 2010;7:164-175.
14. Goadsby PJ et al. Ann Neurol 1993;33:48-56.
15. Edvinsson L et al. Nat Rev Neurol 2018;14:338-350.
16. Liu Y et al. Cephalalgia 2009;29:935-948.
17. Eftekhari S et al. Brain Res 2015;1600:93-109.
18. Edvinsson L et al. Br J Clin Pharm 2015;80:193-199.
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By TEVAProf. Lars Edvinsson showed the audience how calcitonin gene-related peptide (CGRP) gradually became one of the most important molecules in primary headaches. From its discovery in the early 1980s to its role as an important target for novel specific anti-migraine drugs.
1. Edvinsson L et al. Brain Res Rev 2005;48:438-468.
2. Markowitz S et al. J Neurosci 1987;7:4129-4136.
3. Goldstein DJ et al. Cephalalgia 1997;17:785-790.
4. Amara SG et al. Nature 1982;298:240-244.
5. Rosenfeld MG et al. Science 1984;225:1315-1320.
6. Edvinsson L et al. Trends Neurosci 1985;8:126-131.
7. Uddman R et al. Neurosci Lett 1985;62:131-136.
8. McCulloch J et al. PNAS 1986;83:5731-5735.
9. Edvinsson L et al. Pharmacol Toxicol 2001;86:65-73.
10. Edvinsson L et al. Br J Pharmacol 1990;100:312-318.
11. Edvinsson L et al. Cephalalgia 1995;15:272-276.
12. Goadsby PJ et al. Ann Neurol 1988;23:193-196.
13. Edvinsson L et al. Neurotherapeutics 2010;7:164-175.
14. Goadsby PJ et al. Ann Neurol 1993;33:48-56.
15. Edvinsson L et al. Nat Rev Neurol 2018;14:338-350.
16. Liu Y et al. Cephalalgia 2009;29:935-948.
17. Eftekhari S et al. Brain Res 2015;1600:93-109.
18. Edvinsson L et al. Br J Clin Pharm 2015;80:193-199.