The sermon emphasizes the inevitability and blessing of change, drawing parallels from the transition of leadership in the Old Testament and the need for adaptability within the church. It encourages embracing change with courage and a mind to work, highlighting the importance of unity, prayer, and faithfulness to core doctrines while remaining open to new leadership and opportunities. The message underscores the value of shared purpose, mutual support, and a commitment to spreading the gospel, ultimately calling for a community that remains steadfast in faith and open to God's direction.