Before 1947, leukemia was understood to be an untreatable disease, but Dr. Sidney Farber refused to accept this conclusion, and used antifolates, to hopefully restore normal blood.Sidney Farber 1903 - 1973ttps://www.healio.com/hematology-oncology/news/print/hemonc-today/%7B5d9e673c-c88e-43a1-9122-55037e2eb7c7%7D/sidney-farber-1903-1973The Emperor of All Maladies: A Biography of Cancer. Siddartha Mukherjee, M.D. 2010.Buffalo NY flu 1918 - flu encyclopediahttps://www.influenzaarchive.org/cities/city-buffalo.html#Sidney Farber, Chemo Crusader - Saul Wisna - May 27, 2015 - WNYC Archive Collectionshttps://www.wnyc.org/story/sidney-farber-chemo-crusader/1918 Spanish Flu Pandemic Historyhttps://www.cdc.gov/flu/pandemic-resources/1918-pandemic-h1n1.htmlBlood specificshttps://www.oneblood.org/about-donating/blood-donor-basics/what-is-blood/University of Rochester Medical SchoolMonocyte to Macrophage - Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases, Yang, Zhang, et. al. National Institute of Health.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892095/Discovery of Leukemia - NY Timeshttps://www.nytimes.com/2012/06/05/health/history-of-battle-against-leukemia.htmlLeukemia Development from Bone Marrowhttps://my.clevelandclinic.org/health/diseases/4365-leukemiaVitamin B12 Information - National Institute of Healthhttps://ods.od.nih.gov/factsheets/VitaminB12-Consumer/Folic acid Information - ScienceDirecthttps://www.sciencedirect.com/topics/chemistry/folic-acidB12 and Folate Deficiency - National Health Service - UKhttps://www.nhs.uk/conditions/vitamin-b12-or-folate-deficiency-anaemia/Folate Deficiency vs Vitamin B12 Deficiency - Medicosis Perfectionalishttps://www.youtube.com/watch?v=XcKsctwgDcgAminopterin drug information - US Library of Medicine https://pubchem.ncbi.nlm.nih.gov/compound/AminopterinTruth or Consequences Broadcast - Ralph Edwards & Einar Gustafson - Dana-Farber Cancer Institute.http://www.jimmyfund.org/about-us/about-the-jimmy-fund/einar-gustafson-jimmy-was-inspiration-for-the-jimmy-fund/Dr. Sidney Farber Interview. Sidney Farber Chemo Crusader. Saul Wisna. May 27th, 2015. WNYC Archive Collections. Support the show (https://www.patreon.com/headcoldpod)