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Generic Name

Chlorpromazine

Trade Name

Thorazine

Indication

Second line treatment of schizophrenia and psychosis, nausea/vomiting, pre-op sedation, acute intermittent porphyria, headache, bipolar

Action

Exhibits anticholinergic activity, alters effects of dopamine in CNS

Therapeutic Class

Antipsychotic, antiemetic

Pharmacologic Class

Phenothiazines (dopamine D2 receptor antagonist)

Nursing Considerations

• May cause neuroleptic malignant syndrome, sedation, tardive dyskinesia, hypotension, agranulocytosis • Assess mental status prior to and during treatment • Monitor blood pressure • Ensure patient is taking medication • Monitor CBC and liver function tests • Instruct patient not to skip doses or double dose.