In JACC's February 17 issue on Women's Heart Health. JACC Deputy Editor Erica Spatz, MD, joins author and JACC Associate Editor Michael Honigberg, MD, FACC, to discuss the need to rethink cholesterol management in women by moving beyond short term, age driven risk calculators toward a life course approach that accounts for cumulative exposure to atherogenic lipoproteins. His piece in our focus issue highlights opportunities for earlier, individualized prevention—including shared decision making around statin therapy and careful consideration of reproductive goals—to better reduce long term cardiovascular risk in women.