This time, Markus and Phil sat down with Owen Jonathan, who brings a refreshingly open and grounded perspective on learning – and teaching – DOE in real biological systems.

What makes Owen’s story so compelling is how honestly he talks about coming into DOE with an open mind, realising what he hadn’t been taught, and then discovering how powerful the methodology becomes when biology is too complex for intuition alone.

A few standout quotes:

🔹 “I didn’t realize until later that I’d never actually been taught DOE.” 🔹 "Progress isn’t about doing more — it’s about asking the right questions first." 🔹 “Biology needs abstraction or it becomes impossible to model.”

If you’re interested in practical experimentation, ML-enabled workflows, or how real scientists bring DOE into messy biology, this one’s packed with insight.